Steve, I have Vista home with Areo enabled and I have very few problems with Alibre. The computer I am using was purchased with XP and I first installed the Vista OS upgrade with the option to return to XP. On that upgrade I had endless problems with Alibre, so after all kinds of calls to Alibre tech support, I specualted that Alibre might not be the problem, and reinstalled the Vista upgrade, without, ugh, the option to rollback. All went well, all the non-Vista compatable software was purged; Vista was nice enough to create a folder "windows.old" that contains most of the data files for the removed software applications. So now, and so far, I am happy with how Vista and Alibre work together, it has been well over 4 months, maybe even 6 months.
I did discover, somewhere along the way, that I had more problems when I was using my Spaceball, especially with large assemblies, so I removed the hardware and uninstalled the driver, which seemed to improve Alibre; one note though, I have not tried to reinstall Spaceball for some time, and possibly the latest drivers might be fine, and if someone is using Vista, Alibre, and Spaceball without any problems, I would like to get back to using Spaceball.
I do remember another issue that came up a couple of weeks after things were working well on the Vista reinstallation, where I thought I would do myself a favor, and I installed the then newest Vista driver for my video card (Radeon X800). Immediately after I installed the new driver I began to have serious problems with Alibre, I rolled back the driver and all was well again. Then, after a few months of happy Vista, and having the urge to torture myself, and proving just how much of a slow learner I am, I agin downloaded and installed the then latest video driver, and oddly it worked just fine, and did not cause any problems with Alibre, and seems to have improved my whole Vista experience.
I do not know how this information will help you with a new Vista computer, but I have not had to do anything special with Vista, other than drivers.
I am sure that everyone else is wiser than me, and will back up anything important, before they...
Regards, Denis