I Have Sp3 On My machine here and have no Alibre Related problems.
However 4 out of 5 computers here at our company suffered the infamous BLUE SCREEN OF DEATH within 48 hours of installing SP3, So Beware. Chkdsk was able to repair 3 of the 4, all but mine which required a complete system reload.
Not Fun, be careful and if BSOD shows up after sp3 install, use chkdsk first to try to resolve it.